replicative senescence การใช้

• Telomere shortening in humans can induce replicative senescence, which blocks cell division.
• This phenomenon is known as " replicative senescence ", or the Hayflick limit.
• JDP2-deficient mouse embryonic fibroblasts are resistant to replicative senescence by recruiting p16Ink4a locus.
• Replicative senescence is the result of telomere shortening that ultimately triggers a DNA damage response.
• Many different stimuli apply checkpoint controls including TGFb, DNA damage, contact inhibition, replicative senescence, and growth factor withdrawal.
• "Nothobranchius furzeri " shows no signs of telomere shortening, reduced telomerase activity, or replicative senescence with age, despite its short lifespan.
• Moreover, cellular senescence is not observed in several organisms, including perennial plants, cellular mitosis; i . e ., cells experience " replicative senescence ".
• Characterized by the limited ability of cultured normal cells to divide, senescence has been shown to be triggered through oncogenic activation ( premature senescence ) as well as telomere shortening as the result of successive rounds of DNA replication ( replicative senescence ).
• Also, it has been theorized that the cells Carrel used were young enough to contain pluripotent stem cells, which, if supplied with a supporting telomerase-activation nutrient, would have been capable of staving off replicative senescence, or even possibly reversing it.
• Further experiments by Andrews and his team demonstrated that the protein component of telomerase was inducible, and that when the gene for that component was inserted into normal human skin cells, they could divide past the Hayflick limit and essentially stopped exhibiting replicative senescence, a likely cause of aging.
• ERCs have not been observed in other species ( nor even all strains of the same yeast species ) of yeast ( which also display replicative senescence ), and ERCs are not believed to contribute to aging in higher organisms such as humans ( they have not been shown to accumulate in mammals in a similar manner to yeast ).